Scientific research into cryotherapy started to appear soon after its invention and still appears. Like any new technology or methodology, cryotherapy has always had its followers and those who doubt its effectiveness. And science is aimed at making it clear.
First researches were general and the subject was mainly how extreme cold effects on the body. The logic of whole body cryotherapy stems from standard-issue cold therapy, which uses ice packs and ice-water baths in treatment. Science has no doubts that cold helps to reduce pain and inflammation; the main question of these researches was about the effect of such low temperatures that whole body cryotherapy uses.
Some research studied the effect of the cold on animals, for example, horses. As a result, localized cryotherapy is now widely used in equine treatment.
Other studies focused on different diseases and chronic conditions and the effect of whole body cryotherapy on them (for example, cancer, rheumatoid arthritis, eczema, dementia, depression, etc.). Conclusions of some of them are ambiguous; that is why scientists remain studying.